API-2

• Supplier: Tocris Bioscience
• Catalog: 3897
• Prices: $279.00
• Sizes: 10 mg
• Function Type: Inhibitor
• Cas Number: 35943-35-2
• Chemical Name: 1,5-Dihydro-5-methyl-1-β-D-ribofuranosyl-1,4,5,6,8-pentaazaacenaphthylen-3-amine
• Formula: C13H16N6O4
• Molecular Weight: 320.31
• Purity: >99 %
• Description: Selective inhibitor of Akt (protein kinase B) signaling; displays minimal inhibition of PKC, PKA, SGK and p38 pathways. Inhibits phosphorylation and activation of downstream targets of Akt including Bad, GSK-3 β and AFX. Induces apoptosis and growth arrest in vitro , preferentially in human cancer cells with elevated levels of Akt. Potently and selectively inhibits growth of Akt-overexpressing tumors in mice. Inhibits DNA synthesis and displays antiviral activity against HIV-1 and -2.

Product References

Dual mechanisms of inhibition of DNA synthesis by triciribine. - Dual mechanisms of inhibition of DNA synthesis by triciribine.

Wotring LL, Townsend LB, Jones LM, Borysko KZ, Gildersleeve DL, Parker WB. Cancer Res. 1990 Aug 15;50(16):4891-9.

Phosphorylation of triciribine is necessary for activity against HIV type 1. - Phosphorylation of triciribine is necessary for activity against HIV type 1.

Ptak RG, Borysko KZ, Porcari AR, Buthod JL, Holland LE, Shipman C Jr, Townsend LB, Drach JC. AIDS Res Hum Retroviruses. 1998 Oct 10;14(15):1315-22.

Akt/protein kinase B signaling inhibitor-2, a selective small molecule inhibitor - Akt/protein kinase B signaling inhibitor-2, a selective small molecule inhibitor

Yang L, Dan HC, Sun M, Liu Q, Sun XM, Feldman RI, Hamilton AD, Polokoff M, Nicosia SV, Herlyn M, Sebti SM, Cheng JQ. Cancer Res. 2004 Jul 1;64(13):4394-9.