( RS )-APICA

• Supplier: Tocris Bioscience
• Catalog: 2151
• Prices: $149.00, $629.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 170847-18-4
• Chemical Name: (RS)-1-Amino-5-phosphonoindan-1-carboxylicacid
• Formula: C10H12NO5P
• Molecular Weight: 257.18
• Description: Rigidified analog of MPPG (Cat. No. 0853); selective group II metabotropic glutamate receptor antagonist (IC 50 = 30 μ M) with no significant effect on group I and III mGlu receptors at concentrations up to 1 mM. Increases extracellular glutamate concentrations and possesses unusual inverse agonist-like action.

Product References

Group I, II, and III mGluR compounds affect rhythm generation in the gastric - Group I, II, and III mGluR compounds affect rhythm generation in the gastric

Krenz WD, Nguyen D, Perez-Acevedo NL, Selverston AI. J Neurophysiol. 2000 Mar;83(3):1188-201.

Group II metabotropic glutamate receptors modulate extracellular glutamate in the - Group II metabotropic glutamate receptors modulate extracellular glutamate in the

Xi ZX, Baker DA, Shen H, Carson DS, Kalivas PW. J Pharmacol Exp Ther. 2002 Jan;300(1):162-71.