Apicidin

• Supplier: Tocris Bioscience
• Catalog: 1073
• Prices: $129.00
• Sizes: 1 mg
• Function Type: Inhibitor
• Cas Number: 183506-66-3
• Chemical Name: Cyclo[(2S)-2-Amino-8-oxodecanoyl-1-methoxy-L-tryptophyl-L-isoleucyl-(2R)-2-piperidinecarbonyl]
• Formula: C34H49N5O6
• Molecular Weight: 623.78
• Purity: >98 %
• Description: Potent histone deacetylase (HDAC) inhibitor (IC 50 = 0.7 nM in an enzyme activity assay). Antiangiogenic and anti-invasive; blocks proliferation of human stomach and breast cancer cells. Induces apoptosis and autophagy in human oral squamous carcinoma cells.

Product References

Apicidin: a novel antiprotozoal agent that inhibits parasite histone deacetylase. - Apicidin: a novel antiprotozoal agent that inhibits parasite histone deacetylase.

Darkin-Rattray SJ, Gurnett AM, Myers RW, Dulski PM, Crumley TM, Allocco JJ, Cannova C, Meinke PT, Colletti SL, Bednarek MA, Singh SB, Goetz MA, Dombrowski AW, Polishook JD, Schmatz DM. Proc Natl Acad Sci U S A. 1996 Nov 12;93(23):13143-7.

Apicidin, a histone deacetylase inhibitor, inhibits proliferation of tumor cells - Apicidin, a histone deacetylase inhibitor, inhibits proliferation of tumor cells

Han JW, Ahn SH, Park SH, Wang SY, Bae GU, Seo DW, Kwon HK, Hong S, Lee HY, Lee YW, Lee HW. Cancer Res. 2000 Nov 1;60(21):6068-74.

Apicidin is a histone deacetylase inhibitor with anti-invasive and - Apicidin is a histone deacetylase inhibitor with anti-invasive and

Kim SH, Ahn S, Han JW, Lee HW, Lee HY, Lee YW, Kim MR, Kim KW, Kim WB, Hong S. Biochem Biophys Res Commun. 2004 Mar 19;315(4):964-70.

Apicidin, a histone deaceylase inhibitor, induces both apoptosis and autophagy in - Apicidin, a histone deaceylase inhibitor, induces both apoptosis and autophagy in

Ahn MY, Ahn SG, Yoon JH. Oral Oncol. 2011 Nov;47(11):1032-8.