Apigenin

• Supplier: Tocris Bioscience
• Catalog: 4846
• Prices: $59.00, $199.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 520-36-5
• Chemical Name: 5,7-Dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
• Formula: C15H10O5
• Molecular Weight: 270.2
• Purity: >97 %
• Description: Protein kinase inhibitor. Suppresses tumor-promoting effects of TPA and exhibits antiproliferative activity in human breast cancer cells (IC 50 values are 59.44 and 31.15 μ M at 24 and 72 hrs respectively). Activates both the intrinsic and extrinsic apoptotic pathways and displays anti-inflammatory, hypotensive, antispasmodic and antioxidant properties in vivo .

Product References

Apigenin induces morphological differentiation and G2-M arrest in rat neuronal - Apigenin induces morphological differentiation and G2-M arrest in rat neuronal

Sato F, Matsukawa Y, Matsumoto K, Nishino H, Sakai T. Biochem Biophys Res Commun. 1994 Oct 28;204(2):578-84.

Reversion of v-H-ras-transformed NIH 3T3 cells by apigenin through inhibiting - Reversion of v-H-ras-transformed NIH 3T3 cells by apigenin through inhibiting

Kuo ML, Yang NC. Biochem Biophys Res Commun. 1995 Jul 26;212(3):767-75.

Suppression of protein kinase C and nuclear oncogene expression as possible - Suppression of protein kinase C and nuclear oncogene expression as possible

Lin JK, Chen YC, Huang YT, Lin-Shiau SY. J Cell Biochem Suppl. 1997;28-29:39-48.

Apigenin Induces Apoptosis through a Mitochondria/Caspase-Pathway in Human Breast - Apigenin Induces Apoptosis through a Mitochondria/Caspase-Pathway in Human Breast

Choi EJ, Kim GH. J Clin Biochem Nutr. 2009 May;44(3):260-5.

Apigenin protects endothelium-dependent relaxation of rat aorta against oxidative - Apigenin protects endothelium-dependent relaxation of rat aorta against oxidative

Jin BH, Qian LB, Chen S, Li J, Wang HP, Bruce IC, Lin J, Xia Q. Eur J Pharmacol. 2009 Aug 15;616(1-3):200-5.