( R )-(-)-Apomorphine hydrochloride

• Supplier: Tocris Bioscience
• Catalog: 4663
• Prices: $95.00
• Sizes: 50 mg
• Function Type: Agonist
• Cas Number: 314-19-2
• Chemical Name: (R)-5,6,6a,7-Tetrahydro-6-methyl-4H-dibenzo[de,g]quinoline-10,11-diolhydrochloride
• Formula: C17H17NO2.HCl
• Molecular Weight: 303.79
• Purity: >99 %
• Description: Prototypical dopamine agonist (pK i values are 6.43, 7.08, 7.59, 8.36 and 7.83 for human recombinant D 1 , D 2L , D 3 , D 4 and D 5 receptors respectively). Produces biphasic effects on locomotor activity, and displays anti-Parkinsonian and neuroprotective actions following systemic administration in vivo .

Product References

Low doses of apomorphine suppress operant motor performance in rats. - Low doses of apomorphine suppress operant motor performance in rats.

Liu X, Strecker RE, Brener JM. Pharmacol Biochem Behav. 1996 Feb;53(2):335-40.

Apomorphine protects against MPTP-induced neurotoxicity in mice. - Apomorphine protects against MPTP-induced neurotoxicity in mice.

Grunblatt E, Mandel S, Berkuzki T, Youdim MB. Mov Disord. 1999 Jul;14(4):612-8.

Differential actions of antiparkinson agents at multiple classes of monoaminergic - Differential actions of antiparkinson agents at multiple classes of monoaminergic

Millan MJ, Maiofiss L, Cussac D, Audinot V, Boutin JA, Newman-Tancredi A. J Pharmacol Exp Ther. 2002 Nov;303(2):791-804.