Apoptosis Activator 2

Name Apoptosis Activator 2
Supplier Tocris Bioscience
Catalog 2073
Prices $159.00, $665.00
Sizes 10 mg, 50 mg
Function Type Activator
Cas Number 79183-19-0
Chemical Name 1-[(3,4-Dichlorophenyl)methyl]-1H-indole-2,3-dione
Formula C15H9Cl2NO2
Molecular Weight 306.14
Purity >99 %
Description Apoptosis activator; promotes the cytochrome c-dependent oligomerization of Apaf-1 into the mature apoptosome. Increases procaspase-9 processing and subsequent caspase-3 activation. Induces apoptosis in tumor cells (IC 50 = 4 - 9 μ M for leukemia cells) with weak or no effect on normal cell lines or those defective/deficient in Apaf-1, caspase-9 or caspase-3 activity (IC 50 > 40 μ M).
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Product References

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