APY 29

• Supplier: Tocris Bioscience
• Catalog: 4139
• Prices: $199.00, $825.00
• Sizes: 10 mg, 50 mg
• Function Type: Modulator
• Cas Number: 1216665-49-4
• Chemical Name: N2-1H-Benzimidazol-6-yl-N4-(5-cyclopropyl-1H-pyrazol-3-yl)-2,4-pyrimidinediamine
• Formula: C17H16N8
• Molecular Weight: 332.36
• Purity: >98 %
• Description: Allosteric modulator of IRE1 α . Inhibits IRE1 α autophosphorylation (IC 50 = 280 nM) and activates IRE1 α ribonuclease activity.

Product References

The unfolded protein response signals through high-order assembly of Ire1. - The unfolded protein response signals through high-order assembly of Ire1.

Korennykh AV, Egea PF, Korostelev AA, Finer-Moore J, Zhang C, Shokat KM, Stroud RM, Walter P. Nature. 2009 Feb 5;457(7230):687-93.

Divergent allosteric control of the IRE1alpha endoribonuclease using kinase - Divergent allosteric control of the IRE1alpha endoribonuclease using kinase

Wang L, Perera BG, Hari SB, Bhhatarai B, Backes BJ, Seeliger MA, Schurer SC, Oakes SA, Papa FR, Maly DJ. Nat Chem Biol. 2012 Dec;8(12):982-9.