AQ-RA 741

• Supplier: Tocris Bioscience
• Catalog: 0666
• Prices: $149.00, $629.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 123548-16-3
• Chemical Name: 11-[[4-[4-(Diethylamino)butyl]-1-piperidinyl]acetyl]-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one
• Formula: C27H37N5O2
• Molecular Weight: 463.62
• Purity: >99 %
• Description: High affinity, selective muscarinic M 2 receptor antagonist (pK i values are 8.3, 7.7 and 6.82 for M 2 , M 1 and M 3 receptors, respectively). Displays cardioselectivity in vivo , over intestinal, tracheal and bladder muscarinic receptors; inhibits vagally and agonist-induced bradycardia.

Product References

Cardioselectivity of AQ-RA 741, a novel tricyclic antimuscarinic drug. - Cardioselectivity of AQ-RA 741, a novel tricyclic antimuscarinic drug.

Doods H, Entzeroth M, Mayer N. Eur J Pharmacol. 1991 Jan 3;192(1):147-52.

Antagonist binding profiles of five cloned human muscarinic receptor subtypes. - Antagonist binding profiles of five cloned human muscarinic receptor subtypes.

Dorje F, Wess J, Lambrecht G, Tacke R, Mutschler E, Brann MR. J Pharmacol Exp Ther. 1991 Feb;256(2):727-33.

Pharmacological profile of selective muscarinic receptor antagonists on - Pharmacological profile of selective muscarinic receptor antagonists on

Doods HN, Entzeroth M, Ziegler H, Mayer N, Holzer P. Eur J Pharmacol. 1994 Mar 3;253(3):275-81.