AR-A 014418

• Supplier: Tocris Bioscience
• Catalog: 2292
• Prices: $169.00, $705.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 487021-52-3
• Chemical Name: N-[(4-Methoxyphenyl)methyl]-N'-(5-nitro-2-thiazolyl)urea
• Formula: C12H12N4O4S
• Molecular Weight: 308.31
• Purity: >99 %
• Description: Selective glycogen synthase kinase 3 (GSK-3) inhibitor (IC 50 = 104 nM). Exhibits specificity for GSK-3 over cdk2 and cdk5 (IC 50 values are > 100 μ M) and over 26 other kinases. Inhibits β -amyloid-mediated neurodegeneration in hippocampal slices.

Product References

GSK3beta signalling: casting a wide net in Alzheimer's disease. - GSK3beta signalling: casting a wide net in Alzheimer's disease.

Bhat RV, Budd SL. Neurosignals. 2002 Sep-Oct;11(5):251-61.

Structural insights and biological effects of glycogen synthase kinase 3-specific - Structural insights and biological effects of glycogen synthase kinase 3-specific

Bhat R, Xue Y, Berg S, Hellberg S, Ormo M, Nilsson Y, Radesater AC, Jerning E, Markgren PO, Borgegard T, Nylof M, Gimenez-Cassina A, Hernandez F, Lucas JJ, Diaz-Nido J, Avila J. J Biol Chem. 2003 Nov 14;278(46):45937-45. Epub 2003 Aug 19.

AR-A014418, a selective GSK-3 inhibitor, produces antidepressant-like effects in - AR-A014418, a selective GSK-3 inhibitor, produces antidepressant-like effects in

Gould TD, Einat H, Bhat R, Manji HK. Int J Neuropsychopharmacol. 2004 Dec;7(4):387-90. Epub 2004 Jul 26.