Arachidonyl serotonin

• Supplier: Tocris Bioscience
• Catalog: 2756
• Prices: $105.00
• Sizes: 10 mg
• Function Type: Antagonist
• Cas Number: 187947-37-1
• Chemical Name: N-[2-(5-Hydroxy-1H-indol-3-yl)ethyl]-5,8,11,14-eicosatetraenamide
• Formula: C30H42N2O2
• Molecular Weight: 462.67
• Description: Dual fatty acid amide hydrolase (FAAH) inhibitor/TRPV1 antagonist (IC 50 values are 5.6 μ M and 37 - 40 nM for FAAH and TRPV1 respectively). Inactive at cPLA 2 , CB 1 or 5-HT receptors. Displays strong analgesic activity against both acute and chronic peripheral pain.

Product References

The endocannabinoid system and its therapeutic exploitation. - The endocannabinoid system and its therapeutic exploitation.

Di Marzo V, Bifulco M, De Petrocellis L. Nat Rev Drug Discov. 2004 Sep;3(9):771-84.

Analgesic actions of N-arachidonoyl-serotonin, a fatty acid amide hydrolase - Analgesic actions of N-arachidonoyl-serotonin, a fatty acid amide hydrolase

Maione S, De Petrocellis L, de Novellis V, Moriello AS, Petrosino S, Palazzo E, Rossi FS, Woodward DF, Di Marzo V. Br J Pharmacol. 2007 Mar;150(6):766-81. Epub 2007 Feb 5.