2-Arachidonylglycerol

• Supplier: Tocris Bioscience
• Catalog: 1814
• Prices: $189.00
• Sizes: 10 mg
• Function Type: Agonist
• Cas Number: 53847-30-6
• Chemical Name: (5Z,8Z,11Z,14Z)-5,8,11,14-Eicosatetraenoicacid,2-hydroxy-1-(hydroxymethyl)ethylester
• Formula: C23H38O4
• Molecular Weight: 378.55
• Description: Endogenous cannabinoid ligand that acts as a potent agonist at GPR55 (EC 50 values are 3, 519 and 618 nM at GPR55, CB 1 and CB 2 respectively; K i values are 472 and 1400 nM at CB 1 and CB 2 respectively). Found in the brain at concentrations 1000-fold higher than that of anandamide. Effects are enhanced by combined administration with 2-palmitoylglycerol (Cat. No. 2206) in vivo .

Product References

Identification of an endogenous 2-monoglyceride, present in canine gut, that - Identification of an endogenous 2-monoglyceride, present in canine gut, that

Mechoulam R, Ben-Shabat S, Hanus L, Ligumsky M, Kaminski NE, Schatz AR, Gopher A, Almog S, Martin BR, Compton DR, et al.. Biochem Pharmacol. 1995 Jun 29;50(1):83-90.

Evidence that the cannabinoid CB1 receptor is a 2-arachidonoylglycerol receptor. - Evidence that the cannabinoid CB1 receptor is a 2-arachidonoylglycerol receptor.

Sugiura T, Kodaka T, Nakane S, Miyashita T, Kondo S, Suhara Y, Takayama H, Waku K, Seki C, Baba N, Ishima Y. J Biol Chem. 1999 Jan 29;274(5):2794-801.

Evidence that 2-arachidonoylglycerol but not N-palmitoylethanolamine or - Evidence that 2-arachidonoylglycerol but not N-palmitoylethanolamine or

Sugiura T, Kondo S, Kishimoto S, Miyashita T, Nakane S, Kodaka T, Suhara Y, Takayama H, Waku K. J Biol Chem. 2000 Jan 7;275(1):605-12.

The orphan receptor GPR55 is a novel cannabinoid receptor. - The orphan receptor GPR55 is a novel cannabinoid receptor.

Ryberg E, Larsson N, Sjogren S, Hjorth S, Hermansson NO, Leonova J, Elebring T, Nilsson K, Drmota T, Greasley PJ. Br J Pharmacol. 2007 Dec;152(7):1092-101. Epub 2007 Sep 17.