N -Arachidonylglycine

• Supplier: Tocris Bioscience
• Catalog: 1298
• Prices: $115.00, $485.00
• Sizes: 5 mg, 25 mg
• Cas Number: 179113-91-8
• Chemical Name: N-(1-oxo-5Z,8Z,11Z,14Z-eicosatetraenyl)glycine
• Formula: C22H35NO3
• Molecular Weight: 361.52
• Description: Endogenous anandamide-like compound. Lacks affinity for CB 1 receptors (K i > 10 μ M), VR1 receptors (EC 50 > 10 μ M) and anandamide transporters (IC 50 > 50 μ M) but causes hot-plate analgesia in mice when given orally, and suppresses tonic inflammatory pain. Also endogenous GlyT2 inhibitor.

Product References

Structural requirements for binding of anandamide-type compounds to the brain - Structural requirements for binding of anandamide-type compounds to the brain

Sheskin T, Hanus L, Slager J, Vogel Z, Mechoulam R. J Med Chem. 1997 Feb 28;40(5):659-67.

Oxidative metabolism of anandamide. - Oxidative metabolism of anandamide.

Burstein SH, Rossetti RG, Yagen B, Zurier RB. Prostaglandins Other Lipid Mediat. 2000 Apr;61(1-2):29-41.

Identification of a new class of molecules, the arachidonyl amino acids, and - Identification of a new class of molecules, the arachidonyl amino acids, and

Huang SM, Bisogno T, Petros TJ, Chang SY, Zavitsanos PA, Zipkin RE, Sivakumar R, Coop A, Maeda DY, De Petrocellis L, Burstein S, Di Marzo V, Walker JM. J Biol Chem. 2001 Nov 16;276(46):42639-44. Epub 2001 Aug 22.

Extracellular loops 2 and 4 of GLYT2 are required for N-arachidonylglycine - Extracellular loops 2 and 4 of GLYT2 are required for N-arachidonylglycine

Edington AR, McKinzie AA, Reynolds AJ, Kassiou M, Ryan RM, Vandenberg RJ. J Biol Chem. 2009 Dec 25;284(52):36424-30.