Arctigenin

• Supplier: Tocris Bioscience
• Catalog: 0389
• Prices: $89.00, $375.00
• Sizes: 10 mg, 50 mg
• Function Type: Antioxidant
• Cas Number: 7770-78-7
• Chemical Name: (3R,4R)-4-[(3,4-Dimethoxyphenyl)methyl]dihydro-3-[(4-hydroxy-3-methoxyphenyl)methyl]-2(3H)-furanone
• Formula: C21H24O6
• Molecular Weight: 372.42
• Purity: >98 %
• Description: Antioxidant, anti-inflammatory, antiproliferative and antiviral agent. Inhibits LPS-induced iNOS expression via inhibition of I κ B α phosphorylation and p65 nuclear translocation (IC 50 = 10 nM). Inhibits HIV-1 replication in vitro . Also potently inhibits MKK1 (MEK1) (IC 50 = 0.5 nM) and provides neuroprotection by binding to kainate receptors.

Product References

Differential in vitro anti-HIV activity of natural lignans. - Differential in vitro anti-HIV activity of natural lignans.

Schroder HC, Merz H, Steffen R, Muller WE, Sarin PS, Trumm S, Schulz J, Eich E. Z Naturforsch C. 1990 Nov-Dec;45(11-12):1215-21.

Potent inhibition of lipopolysaccharide-inducible nitric oxide synthase - Potent inhibition of lipopolysaccharide-inducible nitric oxide synthase

Cho MK, Park JW, Jang YP, Kim YC, Kim SG. Int Immunopharmacol. 2002 Jan;2(1):105-16.

Arctigenin protects cultured cortical neurons from glutamate-induced - Arctigenin protects cultured cortical neurons from glutamate-induced

Jang YP, Kim SR, Choi YH, Kim J, Kim SG, Markelonis GJ, Oh TH, Kim YC. J Neurosci Res. 2002 Apr 15;68(2):233-40.