| Name | ARL 17477 dihydrochloride |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 5584 |
| Prices | $139.00, $585.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Inhibitor |
| Cas Number | 866914-87-6 |
| Chemical Name | N-[4-[2-[[(3-Chlorophenyl)methyl]amino]ethyl]phenyl]-2-thiophenecarboxamidedihydrochloride |
| Formula | C20H20ClN3S.2HCl |
| Molecular Weight | 442.83 |
| Purity | >99 % |
| Description | Selective neuronal nitrogen oxide synthase (nNOS) inhibitor (IC 50 values are 1 and 17 μ M for nNOS and endothelial NOS respectively). Reduces ischemic cell damage after middle cerebral artery (MCA) occlusion in rats. Displays a synergistic neuroprotective effect when combined with either an NMDA or AMPA receptor antagonist. |
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Hicks CA, Ward MA, Swettenham JB, O'Neill MJ. Eur J Pharmacol. 1999 Sep 24;381(2-3):113-9.
O'Neill MJ, Murray TK, McCarty DR, Hicks CA, Dell CP, Patrick KE, Ward MA, Osborne DJ, Wiernicki TR, Roman CR, Lodge D, Fleisch JH, Singh J. Brain Res. 2000 Jul 21;871(2):234-44.