ARN 272

• Supplier: Tocris Bioscience
• Catalog: 2699
• Prices: $279.00
• Sizes: 10 mg
• Function Type: Inhibitor
• Cas Number: 488793-85-7
• Chemical Name: 4-[[4-(4-Hydroxyphenyl)-1-phthalazinyl]amino]-N-phenylbenzamide
• Formula: C27H20N4O2
• Molecular Weight: 432.47
• Purity: >98 %
• Description: FAAH-like anandamide transporter (FLAT) inhibitor (IC 50 = 1.8 μ M); cytosolic variant of FAAH-1 that binds anandamide. Attenuates anandamide internalization and deactivation in vitro and in vivo respectively. Exhibits analgesic effects in rodent models of CB 1 -mediated nociceptive and inflammatory pain.

Product References

A catalytically silent FAAH-1 variant drives anandamide transport in neurons. - A catalytically silent FAAH-1 variant drives anandamide transport in neurons.

Fu J, Bottegoni G, Sasso O, Bertorelli R, Rocchia W, Masetti M, Guijarro A, Lodola A, Armirotti A, Garau G, Bandiera T, Reggiani A, Mor M, Cavalli A, Piomelli D. Nat Neurosci. 2011 Nov 20;15(1):64-9.

"Redundancy" of endocannabinoid inactivation: new challenges and opportunities - "Redundancy" of endocannabinoid inactivation: new challenges and opportunities

Piscitelli F, Di Marzo V. ACS Chem Neurosci. 2012 May 16;3(5):356-63.