ARP 100

• Supplier: Tocris Bioscience
• Catalog: 4574
• Prices: $129.00
• Sizes: 5 mg
• Function Type: Inhibitor
• Cas Number: 704888-90-4
• Chemical Name: 2-[((1,1'-Biphenyl)-4-ylsulfonyl)-(1-methylethoxy)amino]-N-hydroxyacetamide
• Formula: C17H20N2O5S
• Molecular Weight: 364.42
• Purity: >99 %
• Description: Selective inhibitor of MMP-2 (IC 50 = 12 nM); displays selectivity over MMP-9, MMP-3, MMP-1 and MMP-7 (IC 50 values are 200, 4500, > 50000 and > 50000 nM respectively). Exhibits anti-invasive properties in HT1080 fibrosarcoma cells.

Product References

New N-arylsulfonyl-N-alkoxyaminoacetohydroxamic acids as selective inhibitors of - New N-arylsulfonyl-N-alkoxyaminoacetohydroxamic acids as selective inhibitors of

Rossello A, Nuti E, Orlandini E, Carelli P, Rapposelli S, Macchia M, Minutolo F, Carbonaro L, Albini A, Benelli R, Cercignani G, Murphy G, Balsamo A. Bioorg Med Chem. 2004 May 1;12(9):2441-50.

Amber force field implementation, molecular modelling study, synthesis and - Amber force field implementation, molecular modelling study, synthesis and

Tuccinardi T, Martinelli A, Nuti E, Carelli P, Balzano F, Uccello-Barretta G, Murphy G, Rossello A. Bioorg Med Chem. 2006 Jun 15;14(12):4260-76. Epub 2006 Feb 17.