ARRY 520 trifluoroacetate

• Supplier: Tocris Bioscience
• Catalog: 3964
• Prices: $225.00
• Sizes: 10 mg
• Function Type: Inhibitor
• Cas Number: 885060-09-3
• Chemical Name: (2S)-2-(3-Aminopropyl)-5-(2,5-difluorophenyl)-N-methoxy-N-methyl-2-phenyl-1,3,4-thiadiazole-3(2H)-carboxamidetrifluoroacetate
• Formula: C20H22F2N4O2S.CF3CO2H
• Molecular Weight: 420.48
• Purity: >98 %
• Description: Potent kinesin spindle protein (KSP) inhibitor (IC 50 = 6 nM); selective for KSP over >250 other receptors and kinases at a concentration of 10 μ M. Displays robust antitumor activity in bortezomib-resistant xenografts either alone or in combination with bortezomib. Induces degradation of Mcl-1; exhibits comparable cytotoxic activity to taxol (Cat. No. 1097) in epithelial ovarian cancer cells. Active in vivo .

Product References

KSP inhibitor ARRY-520 as a substitute for Paclitaxel in Type I ovarian cancer - KSP inhibitor ARRY-520 as a substitute for Paclitaxel in Type I ovarian cancer

Kim KH, Xie Y, Tytler EM, Woessner R, Mor G, Alvero AB. J Transl Med. 2009 Jul 20;7:63.

ARRY-520, a novel KSP inhibitor with potent activity in hematological and - ARRY-520, a novel KSP inhibitor with potent activity in hematological and

Woessner R, Tunquist B, Lemieux C, Chlipala E, Jackinsky S, Dewolf W Jr, Voegtli W, Cox A, Rana S, Lee P, Walker D. Anticancer Res. 2009 Nov;29(11):4373-80.

Mcl-1 stability determines mitotic cell fate of human multiple myeloma tumor - Mcl-1 stability determines mitotic cell fate of human multiple myeloma tumor

Tunquist BJ, Woessner RD, Walker DH. Mol Cancer Ther. 2010 Jul;9(7):2046-56.