Artemisinin

• Supplier: Tocris Bioscience
• Catalog: 4676
• Prices: $75.00
• Sizes: 50 mg
• Cas Number: 63968-64-9
• Chemical Name: (3R,5aS,6R,8aS,9R,12S,12aR)-Octahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10(3H)-one
• Formula: C15H22O5
• Molecular Weight: 282.33
• Purity: >99 %
• Description: Antimalarial agent; interacts with heme to produce carbon-centred free radicals, causes protein alkylation and damages parasite microorganelles and membranes. Also selectively inhibits the P-type ATPase (PfATP6) of Plasmodium falciparum (K i ~ 150 nM). Displays antiangiogenic effects in mouse embryonic stem cell-derived embryoid bodies.

Product References

Artemisinin and its derivatives: an important new class of antimalarial agents. - Artemisinin and its derivatives: an important new class of antimalarial agents.

Balint GA. Pharmacol Ther. 2001 May-Jun;90(2-3):261-5.

Artemisinins target the SERCA of Plasmodium falciparum. - Artemisinins target the SERCA of Plasmodium falciparum.

Eckstein-Ludwig U, Webb RJ, Van Goethem ID, East JM, Lee AG, Kimura M, O'Neill PM, Bray PG, Ward SA, Krishna S. Nature. 2003 Aug 21;424(6951):957-61.

The antimalaria agent artemisinin exerts antiangiogenic effects in mouse - The antimalaria agent artemisinin exerts antiangiogenic effects in mouse

Wartenberg M, Wolf S, Budde P, Grunheck F, Acker H, Hescheler J, Wartenberg G, Sauer H. Lab Invest. 2003 Nov;83(11):1647-55.