AS 1269574

• Supplier: Tocris Bioscience
• Catalog: 2446
• Prices: $175.00, $709.00
• Sizes: 10 mg, 50 mg
• Function Type: Agonist
• Cas Number: 330981-72-1
• Chemical Name: 2-[[2-(4-Bromophenyl)-6-methyl-4-pyrimidinyl]amino]ethanol
• Formula: C13H14BrN3O
• Molecular Weight: 308.17
• Purity: >98 %
• Description: GPR119 receptor agonist (EC 50 = 2.5 μ M in HEK293 cells expressing human GPR119). Enhances insulin secretion stimulated by glucose in vivo . Stimulates proglucagon gene promoter actvity. Orally available.

Product References

Identification of a novel GPR119 agonist, AS1269574, with in vitro and in vivo - Identification of a novel GPR119 agonist, AS1269574, with in vitro and in vivo

Yoshida S, Ohishi T, Matsui T, Shibasaki M. Biochem Biophys Res Commun. 2010 Sep 24;400(3):437-41. doi:

Stimulation of proglucagon gene expression by human GPR119 in enteroendocrine - Stimulation of proglucagon gene expression by human GPR119 in enteroendocrine

Chepurny OG, Bertinetti D, Diskar M, Leech CA, Afshari P, Tsalkova T, Cheng X, Schwede F, Genieser HG, Herberg FW, Holz GG. Mol Endocrinol. 2013 Aug;27(8):1267-82.