| Name | AS 1892802 |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 4177 |
| Prices | $255.00, $1,045.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Inhibitor |
| Cas Number | 928320-12-1 |
| Chemical Name | N-[(1S)-2-Hydroxy-1-phenylethyl]-N'-[4-(4-pyridinyl)phenyl]-urea |
| Formula | C20H19N3O2 |
| Molecular Weight | 333.38 |
| Purity | >99 % |
| Description | Potent, ATP-competitive ROCK inhibitor (IC 50 values are 52, 57 and 122 nM for human ROCK2, rat ROCK2 and human ROCK1 respectively by ELISA); also inhibits PKAC- α and PRKX (IC 50 values are 200 and 325 nM respectively). Exhibits analgesic effects in rat models of inflammatory (AIA) and noninflammatory (MIA) arthritic pain. Orally bioavailable. |
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Yoshimi E, Kumakura F, Hatori C, Hamachi E, Iwashita A, Ishii N, Terasawa T, Shimizu Y, Takeshita N. J Pharmacol Exp Ther. 2010 Sep 1;334(3):955-63.
Li R, Martin MP, Liu Y, Wang B, Patel RA, Zhu JY, Sun N, Pireddu R, Lawrence NJ, Li J, Haura EB, Sung SS, Guida WC, Schonbrunn E, Sebti SM. J Med Chem. 2012 Mar 8;55(5):2474-8.