| Name | AS 1949490 |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 1968 |
| Prices | $155.00, $645.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Inhibitor |
| Cas Number | 1203680-76-5 |
| Chemical Name | 3-[(4-Chlorophenyl)methoxy]-N-[(1S)-1-phenylethyl]thiophene-2-carboxamide |
| Formula | C20H18ClNO2S |
| Molecular Weight | 371.88 |
| Purity | >99 % |
| Description | Selective SHIP2 (SH2 domain-containing inositol 5'-phosphatase 2) inhibitor (IC 50 values are 0.34 μ M and 0.62 μ M for mouse and human respectively); displays approximately 30-fold affinity for SHIP2 over SHIP1. Increases insulin-induced phosphorylation of Akt in L6 myotubules. Stimulates activation of glucose metabolism; regulates gluconeogenesis in vitro and in vivo and exhibits antidiabetic effects. |
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