| Name | Asenapine maleate |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 4055 |
| Prices | $159.00, $665.00 |
| Sizes | 10 mg, 50 mg |
| Cas Number | 85650-56-2 |
| Chemical Name | (3aR*,12bR*)-5-Chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrolemaleate |
| Formula | C17H16ClNO.C4H4O4 |
| Molecular Weight | 401.84 |
| Purity | >98 % |
| Description | Novel psychopharmacologic agent. Displays antagonist activity at 5-HT, dopamine, noradrenalin and histamine receptor subtypes (pK i values are 8.60, 8.40, 10.15, 9.75, 10.46, 8.84, 9.60, 9.94, 8.85, 8.90, 8.84, 9.38, 8.95, 8.93, 8.9, 9.49, 8.91, 9.00 and 8.21 for 5-HT 1A , 5-HT 1B , 5-HT 2A , 5-HT 2B , 5-HT 2C , 5-HT 5A , 5-HT 6 , 5-HT 7 , D 1 , D 2L , D 2S , D 3 , D 4 , α 1A , α 2A , α 2B , α 2C , H 1 and H 2 receptors respectively). Displays no appreciable affinity for muscarinic receptors. Exhibits potent activity in animal models predictive of antipsychotic efficacy. |
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Meltzer HY, Dritselis A, Yasothan U, Kirkpatrick P. Nat Rev Drug Discov. 2009 Nov;8(11):843-4.
Shahid M, Walker GB, Zorn SH, Wong EH. J Psychopharmacol. 2009 Jan;23(1):65-73.