ASP 3026

• Supplier: Tocris Bioscience
• Catalog: 5308
• Prices: $175.00, $709.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 1097917-15-1
• Chemical Name: N2-[2-Methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-1,3,5-triazine-2,4-diamine
• Formula: C29H40N8O3S
• Molecular Weight: 580.74
• Purity: >99 %
• Description: Potent anaplastic lymphoma kinase (ALK) inhibitor (IC 50 = 3.5 nM). Also inhibits Ack and ROS1 activity (IC 50 values are 5.8 and 8.9 nM respectively). Attenuates proliferation, and induces apoptosis of NPM-ALK + T cell anaplastic large-cell lymphoma (ALCL) cells in vitro . Suppresses tumor growth of NPM-ALK + ALCL cell xenografts in mice. Causes tumor shrinkage in hEML4-ALK transgenic mice. Orally available.

Product References

ALK inhibitors in non-small cell lung cancer: crizotinib and beyond. - ALK inhibitors in non-small cell lung cancer: crizotinib and beyond.

Awad MM, Shaw AT. Clin Adv Hematol Oncol. 2014 Jul;12(7):429-39.

The ALK inhibitor ASP3026 eradicates NPM-ALK(+) T-cell anaplastic large-cell - The ALK inhibitor ASP3026 eradicates NPM-ALK(+) T-cell anaplastic large-cell

George SK, Vishwamitra D, Manshouri R, Shi P, Amin HM. Oncotarget. 2014 Jul 30;5(14):5750-63.

The selective anaplastic lymphoma receptor tyrosine kinase inhibitor ASP3026 - The selective anaplastic lymphoma receptor tyrosine kinase inhibitor ASP3026

Mori M, Ueno Y, Konagai S, Fushiki H, Shimada I, Kondoh Y, Saito R, Mori K, Shindou N, Soga T, Sakagami H, Furutani T, Doihara H, Kudoh M, Kuromitsu S. Mol Cancer Ther. 2014 Feb;13(2):329-40.