AT 101

• Supplier: Tocris Bioscience
• Catalog: 2391
• Prices: $155.00, $645.00
• Sizes: 10 mg, 50 mg
• Cas Number: 90141-22-3
• Chemical Name: (-)-1,1',6,6',7,7'-Hexahydroxy-3,3'-dimethyl-5,5'-bis(1-methylethyl)-[2,2'-binaphthalene]-8,8'-dicarboxaldehyde
• Formula: C30H30O8
• Molecular Weight: 518.56
• Purity: >98 %
• Description: R-(-)-enantiomer of gossypol (Cat. No. 1964). Mimics the BH3 domains of Bcl-2, Bcl-XL and Mcl-1. Disrupts heterodimerization of Bcl-2 with proapoptotic family members. Induces apoptosis in vitro through activation of caspase-9; cytotoxic to multiple myeloma and drug-resistant cell lines. Delays onset of androgen-independent growth of VCaP prostate cancer xenografts in vivo .

Product References

In vivo evaluation of AT-101 (R-(-)-gossypol acetic acid) in androgen-independent - In vivo evaluation of AT-101 (R-(-)-gossypol acetic acid) in androgen-independent

Loberg RD, McGregor N, Ying C, Sargent E, Pienta KJ. Neoplasia. 2007 Dec;9(12):1030-7.

R-(-)-gossypol (AT-101) activates programmed cell death in multiple myeloma - R-(-)-gossypol (AT-101) activates programmed cell death in multiple myeloma

Kline MP, Rajkumar SV, Timm MM, Kimlinger TK, Haug JL, Lust JA, Greipp PR, Kumar S. Exp Hematol. 2008 May;36(5):568-76.

AT-101 induces apoptosis in CLL B cells and overcomes stromal cell-mediated Mcl-1 - AT-101 induces apoptosis in CLL B cells and overcomes stromal cell-mediated Mcl-1

Balakrishnan K, Burger JA, Wierda WG, Gandhi V. Blood. 2009 Jan 1;113(1):149-53.