AT 1015

• Supplier: Tocris Bioscience
• Catalog: 3367
• Prices: $175.00, $709.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 190508-50-0
• Chemical Name: N-[2-[4-(5H-Dibenzo[a,d]cyclohepten-5-ylidene)-1-piperidinyl]ethyl]-1-formyl-4-piperidinecarboxamidehydrochloride
• Formula: C29H33N3O2.HCl
• Molecular Weight: 492.05
• Purity: >97 %
• Description: Long-acting 5-HT 2A receptor antagonist; inhibits vasoconstriction and blocks platelet aggregation. Prolongs clotting time in a rat model of thrombus formation; ameliorates laurate-induced peripheral vascular lesions in rodents.

Product References

AT-1015, a novel serotonin (5-HT)2 receptor antagonist, blocks vascular and - AT-1015, a novel serotonin (5-HT)2 receptor antagonist, blocks vascular and

Kihara H, Hirose K, Koganei H, Sasaki N, Yamamoto H, Kimura A, Nishimori T, Shoji M, Yoshimoto R. J Cardiovasc Pharmacol. 2000 Apr;35(4):523-30.

Antithrombotic activity of AT-1015, a potent 5-HT(2A) receptor antagonist, in rat - Antithrombotic activity of AT-1015, a potent 5-HT(2A) receptor antagonist, in rat

Kihara H, Koganei H, Hirose K, Yamamoto H, Yoshimoto R. Eur J Pharmacol. 2001 Dec 21;433(2-3):157-62.

Assessment of affinity and dissociation ability of a newly synthesized 5-HT2 - Assessment of affinity and dissociation ability of a newly synthesized 5-HT2

Rashid M, Watanabe M, Nakazawa M, Nakamura T, Hattori K, Nagatom T. Jpn J Pharmacol. 2001 Nov;87(3):189-94.