AZD 6482

• Supplier: Tocris Bioscience
• Catalog: 5141
• Prices: $255.00, $1,045.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 1173900-33-8
• Chemical Name: (-)-2-[[(1R)-1-[7-Methyl-2-(4-morpholinyl)-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl]ethyl]amino]benzoicacid
• Formula: C22H24N4O4
• Molecular Weight: 408.45
• Purity: >98 %
• Description: Potent and selective inhibitor of PI 3-kinase β (PI 3-K β ) (IC 50 values are 0.69, 13.6, 47.8 and 136 nM for PI 3-K β , PI 3-K δ , PI 3-K γ and PI 3-K α , respectively). Selectively inhibits in vivo growth of the PTEN-deficient tumor xenografts HCC70 and PC3. Also exhibits antithrombotic activity.

Product References

Functional characterization of an isoform-selective inhibitor of PI3K-p110beta as - Functional characterization of an isoform-selective inhibitor of PI3K-p110beta as

Ni J, Liu Q, Xie S, Carlson C, Von T, Vogel K, Riddle S, Benes C, Eck M, Roberts T, Gray N, Zhao J. Cancer Discov. 2012 May;2(5):425-33.

Human target validation of phosphoinositide 3-kinase (PI3K)beta: effects on - Human target validation of phosphoinositide 3-kinase (PI3K)beta: effects on

Nylander S, Kull B, Bjorkman JA, Ulvinge JC, Oakes N, Emanuelsson BM, Andersson M, Skarby T, Inghardt T, Fjellstrom O, Gustafsson D. J Thromb Haemost. 2012 Oct;10(10):2127-36.