| Name | AZD 7762 hydrochloride |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 4839 |
| Prices | $199.00, $825.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Inhibitor |
| Cas Number | 1246094-78-9 |
| Chemical Name | 3-[(Aminocarbonyl)amino]-5-(3-fluorophenyl)-N-(3S)-3-piperidinyl-2-thiophenecarboxamidehydrochloride |
| Formula | C17H19FN4O2S.HCl |
| Molecular Weight | 398.88 |
| Purity | >98 % |
| Description | Potent and selective ATP-competitive inhibitor of Chk1 and Chk2 (IC 50 vales are 5 nM for both kinases); displays at least >10 fold selectivity over a panel of 164 kinases. Potentiates cytotoxicity of DNA-damaging agents. Active in vivo . |
| Supplier Page | Shop |
Zabludoff SD, Deng C, Grondine MR, Sheehy AM, Ashwell S, Caleb BL, Green S, Haye HR, Horn CL, Janetka JW, Liu D, Mouchet E, Ready S, Rosenthal JL, Queva C, Schwartz GK, Taylor KJ, Tse AN, Walker GE, White AM. Mol Cancer Ther. 2008 Sep;7(9):2955-66.
Morgan MA, Parsels LA, Zhao L, Parsels JD, Davis MA, Hassan MC, Arumugarajah S, Hylander-Gans L, Morosini D, Simeone DM, Canman CE, Normolle DP, Zabludoff SD, Maybaum J, Lawrence TS. Cancer Res. 2010 Jun 15;70(12):4972-81.