AZM 475271

• Supplier: Tocris Bioscience
• Catalog: 3771
• Prices: $235.00, $965.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 476159-98-5
• Chemical Name: N-(2-Chloro-5-methoxyphenyl)-6-methoxy
• Formula: C23H27ClN4O3
• Molecular Weight: 442.94
• Purity: >99 %
• Description: Src tyrosine kinase inhibitor. Reduces tumor size, vascularity and metastasis, and increases apoptosis in human pancreatic cells grown in nude mice. Also exhibits antiangiogenic activity in vitro and in vivo . Sensitizes tumor cells to the cytotoxic effects of gemcitabine (Cat. No. 3259).

Product References

Inhibition of SRC tyrosine kinase as treatment for human pancreatic cancer - Inhibition of SRC tyrosine kinase as treatment for human pancreatic cancer

Yezhelyev MV, Koehl G, Guba M, Brabletz T, Jauch KW, Ryan A, Barge A, Green T, Fennell M, Bruns CJ. Clin Cancer Res. 2004 Dec 1;10(23):8028-36.

AP23846, a novel and highly potent Src family kinase inhibitor, reduces vascular - AP23846, a novel and highly potent Src family kinase inhibitor, reduces vascular

Summy JM, Trevino JG, Lesslie DP, Baker CH, Shakespeare WC, Wang Y, Sundaramoorthi R, Metcalf CA 3rd, Keats JA, Sawyer TK, Gallick GE. Mol Cancer Ther. 2005 Dec;4(12):1900-11.