Bafilomycin A1

Name Bafilomycin A1
Supplier Tocris Bioscience
Catalog 1326
Prices $129.00
Sizes 10 µg
Function Type Inhibitor
Cas Number 88899-55-2
Chemical Name (3Z,5E,7R,8S,9S,11E,13E,15S,16R)-8-Hydroxy-16-[(1S,2R,3S)-2-hydroxy-1-methyl-3-[(2R,4R,5S,6R)-tetrahydro-2,4-dihydroxy-5-methyl-6-(1-methylethyl)-2H-pyran-2-yl]butyl]-3,15-dimethoxy-5,7,9,11-tetramethyloxacyclohexadeca-3,5,11,13-tetraen-2-one
Formula C35H58O9
Molecular Weight 622.84
Purity >98 %
Description Highly potent, selective inhibitor of vacuolar H + -ATPases (IC 50 = 0.6 - 1.5 nM in bovine chromaffin granules). Selective for v-ATPase over other ATP hydrolyzing enzymes such as F-ATPases and the H + /K + -ATPase (P-ATPase). Thought to inhibit autophagy either by blocking autophagosome-lysosome fusion (in H4IIE cells), or by blocking lysosomal degradation.
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Product References

Bafilomycin A1 prevents maturation of autophagic vacuoles by inhibiting fusion - Bafilomycin A1 prevents maturation of autophagic vacuoles by inhibiting fusion

Yamamoto A, Tagawa Y, Yoshimori T, Moriyama Y, Masaki R, Tashiro Y. Cell Struct Funct. 1998 Feb;23(1):33-42.

Chemistry and structure activity relationships of bafilomycin A1, a potent and - Chemistry and structure activity relationships of bafilomycin A1, a potent and

Gagliardi S, Rees M, Farina C. Curr Med Chem. 1999 Dec;6(12):1197-212.

Microtubules support production of starvation-induced autophagosomes but not - Microtubules support production of starvation-induced autophagosomes but not

Fass E, Shvets E, Degani I, Hirschberg K, Elazar Z. J Biol Chem. 2006 Nov 24;281(47):36303-16. Epub 2006 Sep 8.