Baicalein

• Supplier: Tocris Bioscience
• Catalog: 3606
• Prices: $95.00
• Sizes: 50 mg
• Function Type: Inhibitor
• Cas Number: 491-67-8
• Chemical Name: 5,6,7-Trihydroxy-2-phenyl-(4H)-1-benzopyran-4-one
• Formula: C15H10O5
• Molecular Weight: 270.24
• Purity: >98 %
• Description: Inhibitor of 5- and platelet 12-lipoxygenases (IC 50 values are 9.5 and 0.12 μ M respectively). Also inhibits Raf-mediated MEK-1 phosphorylation in C6 rat glioma cells and induces G 1 and G 2 cell cycle arrest by decreasing cdk1, cdk2, cyclin D2 and cyclin A expression. Inhibits production of inflammatory cytokines by inhibiting NF- κ B activation.

Product References

Selective inhibition of platelet lipoxygenase by baicalein. - Selective inhibition of platelet lipoxygenase by baicalein.

Sekiya K, Okuda H. Biochem Biophys Res Commun. 1982 Apr 14;105(3):1090-5.

Baicalein induces a dual growth arrest by modulating multiple cell cycle - Baicalein induces a dual growth arrest by modulating multiple cell cycle

Hsu SL, Hsieh YC, Hsieh WC, Chou CJ. Eur J Pharmacol. 2001 Aug 17;425(3):165-71.

Baicalein inhibits Raf-1-mediated phosphorylation of MEK-1 in C6 rat glioma - Baicalein inhibits Raf-1-mediated phosphorylation of MEK-1 in C6 rat glioma

Nakahata N, Tsuchiya C, Nakatani K, Ohizumi Y, Ohkubo S. Eur J Pharmacol. 2003 Feb 7;461(1):1-7.

Baicalein inhibits IL-1beta- and TNF-alpha-induced inflammatory cytokine - Baicalein inhibits IL-1beta- and TNF-alpha-induced inflammatory cytokine

Hsieh CJ, Hall K, Ha T, Li C, Krishnaswamy G, Chi DS. Clin Mol Allergy. 2007 Nov 26;5:5.