BAN ORL 24

• Supplier: Tocris Bioscience
• Catalog: 4810
• Prices: $199.00, $825.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 1401463-54-4
• Chemical Name: (2R)-1-(Phenylmethyl)-N-[3-(spiro[isobenzofuran-1(3H),4'-piperidin]-1-yl)propyl-2-pyrrolidinecarboxamide
• Formula: C27H35N3O2.2HCl
• Molecular Weight: 506.51
• Purity: >97 %
• Description: Potent and selective NOP receptor antagonist (IC 50 values are 0.27, 2500, 6700 and > 10000 nM for NOP, κ -, μ - and δ -receptors respectively). Inhibits nociceptin-induced stimulation of [ 35 S]-GTP γ S binding and Ca 2+ mobilization in CHO cells in vitro and antagonizes NOP agonist-induced reduction in locomotor activity in vivo . Brain penetrant.

Product References

Identification of a novel spiropiperidine opioid receptor-like 1 antagonist class - Identification of a novel spiropiperidine opioid receptor-like 1 antagonist class

Goto Y, Arai-Otsuki S, Tachibana Y, Ichikawa D, Ozaki S, Takahashi H, Iwasawa Y, Okamoto O, Okuda S, Ohta H, Sagara T. J Med Chem. 2006 Feb 9;49(3):847-9.

Pharmacological characterization of the nociceptin/orphanin FQ receptor non - Pharmacological characterization of the nociceptin/orphanin FQ receptor non

Fischetti C, Camarda V, Rizzi A, Pela M, Trapella C, Guerrini R, McDonald J, Lambert DG, Salvadori S, Regoli D, Calo' G. Eur J Pharmacol. 2009 Jul 1;614(1-3):50-7.

1-Benzyl-N-[3-[spiroisobenzofuran-1(3H),4'-piperidin-1-yl]propyl]pyrrolidine-2-ca - 1-Benzyl-N-[3-[spiroisobenzofuran-1(3H),4'-piperidin-1-yl]propyl]pyrrolidine-2-ca

Liao YY, Trapella C, Chiou LC. Eur J Pharmacol. 2009 Mar 15;606(1-3):84-9.