Banoxantrone dihydrochloride

• Supplier: Tocris Bioscience
• Catalog: 3661
• Prices: $189.00, $765.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 252979-56-9
• Chemical Name: 1,4-Bis[[2-(dimethyloxidoamino)ethyl]amino]-5,8-dihydroxy-9,10-anthracenedionedihydrochloride
• Formula: C22H28N4O6.2HCl
• Molecular Weight: 517.4
• Purity: >98 %
• Description: Bioreductive prodrug; activated by hypoxia to yield the topoisomerase II inhibitor AQ4. Displays little to no cytotoxic activity against 60 tumor cell lines tested under oxic conditions (IC 50 >100 μ M). Exhibits anti-tumor efficacy in vivo when combined with oxic cell cytotoxins; enhances the anti-tumor effect of cyclophosphamide (Cat. No. 4091) in a mouse tumor model.

Product References

Enhancement of the anti-tumour effect of cyclophosphamide by the bioreductive - Enhancement of the anti-tumour effect of cyclophosphamide by the bioreductive

Friery OP, Gallagher R, Murray MM, Hughes CM, Galligan ES, McIntyre IA, Patterson LH, Hirst DG, McKeown SR. Br J Cancer. 2000 Apr;82(8):1469-73.

AQ4N: a new approach to hypoxia-activated cancer chemotherapy. - AQ4N: a new approach to hypoxia-activated cancer chemotherapy.

Patterson LH, McKeown SR. Br J Cancer. 2000 Dec;83(12):1589-93.

Effects of cytokine-induced macrophages on the response of tumor cells to - Effects of cytokine-induced macrophages on the response of tumor cells to

Mehibel M, Singh S, Chinje EC, Cowen RL, Stratford IJ. Mol Cancer Ther. 2009 May;8(5):1261-9.