Batimastat

• Supplier: Tocris Bioscience
• Catalog: 2787
• Prices: $129.00, $279.00
• Sizes: 1 mg, 10 mg
• Function Type: Inhibitor
• Cas Number: 130370-60-4
• Chemical Name: (2R,3S)-N4-Hydroxy-N1-[(1S)-2-(methylamino)-2-oxo-1-(phenylmethyl)ethyl]-2-(2-methylpropyl)-3-[(2-thienylthio)methyl]butanediamide
• Formula: C23H31N3O4S2
• Molecular Weight: 477.64
• Purity: >99 %
• Description: Potent, broad spectrum MMP inhibitor (IC 50 values are 3, 4, 4, 6 and 20 nM for MMP -1, -2, -9, -7 and -3 respectively). Exhibits antiproliferative, anti-invasive and antimetastatic activity in human ovarian carcinoma xenografts in vivo .

Product References

A synthetic matrix metalloproteinase inhibitor decreases tumor burden and - A synthetic matrix metalloproteinase inhibitor decreases tumor burden and

Davies B, Brown PD, East N, Crimmin MJ, Balkwill FR. Cancer Res. 1993 May 1;53(9):2087-91.

Matrix metalloproteinase inhibitor BB-94 (batimastat) inhibits human colon tumor - Matrix metalloproteinase inhibitor BB-94 (batimastat) inhibits human colon tumor

Wang X, Fu X, Brown PD, Crimmin MJ, Hoffman RM. Cancer Res. 1994 Sep 1;54(17):4726-8.

Molecular insights into cancer invasion: strategies for prevention and - Molecular insights into cancer invasion: strategies for prevention and

Kohn EC, Liotta LA. Cancer Res. 1995 May 1;55(9):1856-62.