Bay 11-7085

• Supplier: Tocris Bioscience
• Catalog: 1787
• Prices: $139.00
• Sizes: 10 mg
• Function Type: Inhibitor
• Cas Number: 196309-76-9
• Chemical Name: (2E)-3-[[4-(1,1-Dimethylethyl)phenyl]sulfonyl]-2-propenenitrile
• Formula: C13H15NO2S
• Molecular Weight: 249.33
• Purity: >99 %
• Description: Irreversible inhibitor of TNF- α -stimulated I κ B α phosphorylation (IC 50 ~ 10 μ M); leads to decreased NF- κ B and subsequent decreased expression of adhesion molecules. Also reversibly activates MAP kinases and stimulates apoptosis. Anti-inflammatory in vivo .

Product References

Novel inhibitors of cytokine-induced IkappaBalpha phosphorylation and endothelial - Novel inhibitors of cytokine-induced IkappaBalpha phosphorylation and endothelial

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An IkappaBalpha inhibitor causes leukemia cell death through a p38 MAP - An IkappaBalpha inhibitor causes leukemia cell death through a p38 MAP

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Nuclear factor kappaB inhibitors induce adhesion-dependent colon cancer - Nuclear factor kappaB inhibitors induce adhesion-dependent colon cancer

Scaife CL, Kuang J, Wills JC, Trowbridge DB, Gray P, Manning BM, Eichwald EJ, Daynes RA, Kuwada SK. Cancer Res. 2002 Dec 1;62(23):6870-8.