Bay 11-7821

• Supplier: Tocris Bioscience
• Catalog: 1743
• Prices: $139.00
• Sizes: 10 mg
• Function Type: Inhibitor
• Cas Number: 19542-67-7
• Chemical Name: (2E)-3-[(4-Methylphenyl)sulfonyl]-2-propenenitrile
• Formula: C10H9NO2S
• Molecular Weight: 207.25
• Purity: >99 %
• Description: E2 ubiquitin (Ub) conjugating enzyme inhibitor. Inhibits the conjugation of Ub to a range of E2 enzymes. Inhibits E2 enzyme mediated I κ B α phosphorylation and indirectly decreases NF- κ b activity. Also reversibly activates MAPK signaling. Induces apoptosis of leukemic T cell and B-cell lymphoma cell lines.

Product References

Novel inhibitors of cytokine-induced IkappaBalpha phosphorylation and endothelial - Novel inhibitors of cytokine-induced IkappaBalpha phosphorylation and endothelial

Pierce JW, Schoenleber R, Jesmok G, Best J, Moore SA, Collins T, Gerritsen ME. J Biol Chem. 1997 Aug 22;272(34):21096-103.

Bay 11-7082 inhibits transcription factor NF-kappaB and induces apoptosis of - Bay 11-7082 inhibits transcription factor NF-kappaB and induces apoptosis of

Mori N, Yamada Y, Ikeda S, Yamasaki Y, Tsukasaki K, Tanaka Y, Tomonaga M, Yamamoto N, Fujii M. Blood. 2002 Sep 1;100(5):1828-34.

The anti-inflammatory drug BAY 11-7082 suppresses the MyD88-dependent signalling - The anti-inflammatory drug BAY 11-7082 suppresses the MyD88-dependent signalling

Strickson S, Campbell DG, Emmerich CH, Knebel A, Plater L, Ritorto MS, Shpiro N, Cohen P. Biochem J. 2013 May 1;451(3):427-37.