BAY 41-2272

• Supplier: Tocris Bioscience
• Catalog: 2501
• Prices: $199.00, $825.00
• Sizes: 10 mg, 50 mg
• Function Type: Activator
• Cas Number: 256376-24-6
• Chemical Name: 5-Cyclopropyl-2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-4-pyrimidinamine
• Formula: C20H17FN6
• Molecular Weight: 360.39
• Purity: >98 %
• Description: Activator of soluble guanylyl cyclase (sGC); acts at a nitric oxide (NO)-independent regulatory site in the sGC α 1 subunit. Inhibits platelet aggregation (IC 50 = 36 nM) and phenylephrine-induced contractions of rabbit aorta (IC 50 = 0.30 μ M). Also reduces vascular smooth muscle growth through cAMP- and cGMP-dependent PKA and PKG pathways.

Product References

Discovery of riociguat (BAY 63-2521): a potent, oral stimulator of soluble - Discovery of riociguat (BAY 63-2521): a potent, oral stimulator of soluble

Mittendorf J, Weigand S, Alonso-Alija C, Bischoff E, Feurer A, Gerisch M, Kern A, Knorr A, Lang D, Muenter K, Radtke M, Schirok H, Schlemmer KH, Stahl E, Straub A, Wunder F, Stasch JP. ChemMedChem. 2009 May;4(5):853-65.

NO-independent regulatory site on soluble guanylate cyclase. - NO-independent regulatory site on soluble guanylate cyclase.

Stasch JP, Becker EM, Alonso-Alija C, Apeler H, Dembowsky K, Feurer A, Gerzer R, Minuth T, Perzborn E, Pleiss U, Schroder H, Schroeder W, Stahl E, Steinke W, Straub A, Schramm M. Nature. 2001 Mar 8;410(6825):212-5.

The soluble guanylate cyclase stimulator BAY 41-2272 inhibits vascular smooth - The soluble guanylate cyclase stimulator BAY 41-2272 inhibits vascular smooth

Joshi CN, Martin DN, Fox JC, Mendelev NN, Brown TA, Tulis DA. J Pharmacol Exp Ther. 2011 Nov;339(2):394-402.