BAY 41-8543

• Supplier: Tocris Bioscience
• Catalog: 4430
• Prices: $205.00, $865.00
• Sizes: 10 mg, 50 mg
• Cas Number: 256498-66-5
• Chemical Name: 2-[1-[(2-Fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-(4-morpholinyl)-4,6-pyrimidinediamine
• Formula: C21H21FN8O
• Molecular Weight: 420.44
• Purity: >98 %
• Description: Guanylyl cyclase (sGC) stimulator. Increases activity of sGC by up to 92-fold at concentrations up to 100 μ M. Induces relaxation of aorta, saphenous arteries, coronary arteries and veins in vitro . Inhibits collagen-induced platelet aggregation. Promotes lipid uptake into brown adipose tissue and increases energy expenditure in mice. Induces weight loss in obese mice. Antihypertensive.

Product References

A potent and highly selective VPAC2 agonist enhances glucose-induced insulin - A potent and highly selective VPAC2 agonist enhances glucose-induced insulin

Tsutsumi M, Claus TH, Liang Y, Li Y, Yang L, Zhu J, Dela Cruz F, Peng X, Chen H, Yung SL, Hamren S, Livingston JN, Pan CQ. Diabetes. 2002 May;51(5):1453-60.

Engineering of a VPAC2 receptor peptide agonist to impart dipeptidyl peptidase IV - Engineering of a VPAC2 receptor peptide agonist to impart dipeptidyl peptidase IV

Clairmont KB, Buckholz TM, Pellegrino CM, Buxton JM, Barucci N, Bell A, Ha S, Li F, Claus TH, Salhanick AI, Lumb KJ. J Med Chem. 2006 Dec 14;49(25):7545-8.

Engineering novel VPAC2-selective agonists with improved stability and - Engineering novel VPAC2-selective agonists with improved stability and

Pan CQ, Li F, Tom I, Wang W, Dumas M, Froland W, Yung SL, Li Y, Roczniak S, Claus TH, Wang YJ, Whelan JP. J Pharmacol Exp Ther. 2007 Feb;320(2):900-6. Epub 2006 Nov 16.

Macrophage Resistance to HIV-1 Infection Is Enhanced by the Neuropeptides VIP and - Macrophage Resistance to HIV-1 Infection Is Enhanced by the Neuropeptides VIP and

Temerozo JR, Joaquim R, Regis EG, Savino W, Bou-Habib DC. PLoS One. 2013 Jun 20;8(6):e67701.