(±)-Bay K 8644

Name (±)-Bay K 8644
Supplier Tocris Bioscience
Catalog 4472
Prices $169.00, $705.00
Sizes 10 mg, 50 mg
Function Type Activator
Cas Number 71145-03-4
Chemical Name 1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-3-pyridinecarboxylicacid,methylester
Formula C16H15F3N2O4
Molecular Weight 356.3
Purity >99 %
Description L-type Ca 2+ channel activator (EC 50 = 17.3 nM). Has positive inotropic, vasoconstrictive and behavioral effects in vivo . Separate enantiomers ( R )-(+)-Bay K 8644 and ( S )-(-)-Bay K 8644 also available (Cat. Nos. 1545 and 1546 respectively). In combination with BIX-01294 (Cat. No. 3364), helps generate induced pluripotent stem cells (iPSCs) from mouse embryonic fibroblasts (MEFs). Inhibits autophagy.
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Product References

Calcium channel 'agonist' BAY K 8644 inhibits calcium antagonist binding to brain - Calcium channel 'agonist' BAY K 8644 inhibits calcium antagonist binding to brain

Greenberg DA, Cooper EC, Carpenter CL. Brain Res. 1984 Jul 9;305(2):365-8.

Central and peripheral effects of the dihydropyridine calcium channel activator - Central and peripheral effects of the dihydropyridine calcium channel activator

Bourson A, Moser PC, Gower AJ, Mir AK. Eur J Pharmacol. 1989 Feb 7;160(3):339-47.

Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and - Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and

Shi Y, Desponts C, Do JT, Hahm HS, Scholer HR, Ding S. Cell Stem Cell. 2008 Nov 6;3(5):568-74.

Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of - Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of

Sarkar S, Ravikumar B, Floto RA, Rubinsztein DC. Cell Death Differ. 2009 Jan;16(1):46-56.