BAY-X 1005

• Supplier: Tocris Bioscience
• Catalog: 1546
• Prices: $115.00
• Sizes: 1 mg
• Function Type: Inhibitor
• Cas Number: 128253-31-6
• Chemical Name: (R)-α-Cyclopentyl-4-(2-quinolinylmethoxy)benzeneaceticacid
• Formula: C23H23NO3
• Molecular Weight: 361.43
• Purity: >98 %
• Description: 5-lipoxygenase activating protein (FLAP) inhibitor. Inhibits the synthesis of leukotrienes B 4 and C 4 in animal models; inhibits synthesis of leukotriene B 4 in A23187-stimulated leukocytes (IC 50 values are 0.026, 0.039 and 0.22 μ M for rat, mice and human leukocytes respectively). Displays anti-inflammatory activity. Orally active.

Product References

In vitro pharmacology of BAY X1005, a new inhibitor of leukotriene synthesis. - In vitro pharmacology of BAY X1005, a new inhibitor of leukotriene synthesis.

Fruchtmann R, Mohrs KH, Hatzelmann A, Raddatz S, Fugmann B, Junge B, Horstmann H, Muller-Peddinghaus R. Agents Actions. 1993 Mar;38(3-4):188-95.

BAY X1005, a new inhibitor of leukotriene synthesis: in vivo inflammation - BAY X1005, a new inhibitor of leukotriene synthesis: in vivo inflammation

Muller-Peddinghaus R, Kohlsdorfer C, Theisen-Popp P, Fruchtmann R, Perzborn E, Beckermann B, Buhner K, Ahr HJ, Mohrs KH. J Pharmacol Exp Ther. 1993 Oct;267(1):51-7.

Mode of action of the leukotriene synthesis (FLAP) inhibitor BAY X 1005: - Mode of action of the leukotriene synthesis (FLAP) inhibitor BAY X 1005:

Hatzelmann A, Fruchtmann R, Mohrs KH, Raddatz S, Matzke M, Pleiss U, Keldenich J, Muller-Peddinghaus R. Agents Actions. 1994 Nov;43(1-2):64-8.