BAY-u 3405

• Supplier: Tocris Bioscience
• Catalog: 3541
• Prices: $199.00, $825.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 116649-85-5
• Chemical Name: (3R)-3-[[(4-Fluorophenyl)sulfonyl]amino]-1,2,3,4-tetrahydro-9H-carbazole-9-propanoicacid
• Formula: C21H21FN2O4S
• Molecular Weight: 416.47
• Purity: >99 %
• Description: Potent dual antagonist of TP/DP 2 (CRTH2) prostanoid receptors (K i values are 4.3, 4.5 and > 10000 nM for hDP 2 , hTP and hDP 1 receptors respectively). Suppresses PGD 2 -induced migration of human eosinophils (IC 50 = 170 nM).

Product References

Interactions among three classes of mediators explain antigen-induced - Interactions among three classes of mediators explain antigen-induced

Sundstrom E, Lastbom L, Ryrfeldt A, Dahlen SE. J Pharmacol Exp Ther. 2003 Oct;307(1):408-18. Epub 2003 Sep 3.

Ramatroban (BAY u 3405): a novel dual antagonist of TXA2 receptor and CRTh2, a - Ramatroban (BAY u 3405): a novel dual antagonist of TXA2 receptor and CRTh2, a

Ishizuka T, Matsui T, Okamoto Y, Ohta A, Shichijo M. Cardiovasc Drug Rev. 2004 Summer;22(2):71-90.

Minor structural modifications convert the dual TP/CRTH2 antagonist ramatroban - Minor structural modifications convert the dual TP/CRTH2 antagonist ramatroban

Ulven T, Kostenis E. J Med Chem. 2005 Feb 24;48(4):897-900.