BCTC

• Supplier: Tocris Bioscience
• Catalog: 1048
• Prices: $159.00, $665.00
• Sizes: 10 mg, 50 mg
• Function Type: Antagonist
• Cas Number: 393514-24-4
• Chemical Name: 4-(3-Chloro-2-pyridinyl)-N-[4-(1,1-dimethylethyl)phenyl]-1-piperazinecarboxamide
• Formula: C20H25ClN4O
• Molecular Weight: 372.89
• Purity: >98 %
• Description: Orally effective vanilloid receptor 1 (TRPV1 receptor) antagonist. Inhibits acid- and capsaicin-induced activation of rat TRPV1 receptors (IC 50 values are 6.0 and 35 nM respectively). Displays analgesic properties in rat models of inflammatory and neuropathic pain. CNS penetrant.

Product References

N-(4-Tertiarybutylphenyl)-4-(3-cholorphyridin-2-yl)tetrahydropyrazine - N-(4-Tertiarybutylphenyl)-4-(3-cholorphyridin-2-yl)tetrahydropyrazine

Pomonis JD, Harrison JE, Mark L, Bristol DR, Valenzano KJ, Walker K. J Pharmacol Exp Ther. 2003 Jul;306(1):387-93. Epub 2003 Apr 29.

N-(4-tertiarybutylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine - N-(4-tertiarybutylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine

Valenzano KJ, Grant ER, Wu G, Hachicha M, Schmid L, Tafesse L, Sun Q, Rotshteyn Y, Francis J, Limberis J, Malik S, Whittemore ER, Hodges D. J Pharmacol Exp Ther. 2003 Jul;306(1):377-86. Epub 2003 Apr 29.