BDS I

• Supplier: Tocris Bioscience
• Catalog: 2837
• Prices: $129.00
• Sizes: 10 µg
• Function Type: Blocker
• Formula: C210H297N57O56S6
• Molecular Weight: 4708.37
• Description: Potent and reversible K v 3.4 potassium channel blocker (IC 50 = 47 nM); also attenuates inactivation of sodium currents by acting on Na v 1.7 and Na v 1.3 channels. Enhances TTX-sensitive sodium currents in rat small dorsal root ganglion neurons. Neuroprotective.

Product References

Sea anemone peptides with a specific blocking activity against the fast - Sea anemone peptides with a specific blocking activity against the fast

Diochot S, Schweitz H, Beress L, Lazdunski M. J Biol Chem. 1998 Mar 20;273(12):6744-9.

Up-regulation and increased activity of KV3.4 channels and their accessory - Up-regulation and increased activity of KV3.4 channels and their accessory

Pannaccione A, Boscia F, Scorziello A, Adornetto A, Castaldo P, Sirabella R, Taglialatela M, Di Renzo GF, Annunziato L. Mol Pharmacol. 2007 Sep;72(3):665-73. Epub 2007 May 10.

Modulation of neuronal sodium channels by the sea anemone peptide BDS-I. - Modulation of neuronal sodium channels by the sea anemone peptide BDS-I.

Liu P, Jo S, Bean BP. J Neurophysiol. 2012 Jun;107(11):3155-67.