| Name | Begacestat |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 5467 |
| Prices | $189.00, $765.00 |
| Sizes | 10 mg, 50 mg |
| Function Type | Inhibitor |
| Cas Number | 769169-27-9 |
| Chemical Name | 5-Chloro-N-[(1S)-3,3,3-trifluoro-1-(hydroxymethyl)-2-(trifluoromethyl)propyl]-2-thiophenesulfonamide |
| Formula | C9H8ClF6NO3S2 |
| Molecular Weight | 391.74 |
| Purity | >98 % |
| Description | γ -secretase inhibitor; selectively inhibits cleavage of amyloid precursor protein (APP) over Notch. Lowers levels of A β 42 and A β 40 (EC 50 values are 12.4 and 14.8 nM respectively in cells expressing human recombinant APP). Orally active. |
| Supplier Page | Shop |
Mayer SC, Kreft AF, Harrison B, Abou-Gharbia M, Antane M, Aschmies S, Atchison K, Chlenov M, Cole DC, Comery T, Diamantidis G, Ellingboe J, Fan K, Galante R, Gonzales C, Ho DM, Hoke ME, Hu Y, Huryn D, Jain U, Jin M, Kremer K, Kubrak D, Lin M, Lu P, Magolda R, Martone R, Moore W, Oganesian A, Pangalos MN, Porte A, Reinhart P, Resnick L, Riddell DR, Sonnenberg-Reines J, Stock JR, Sun SC, Wagner E, Wang T, Woller K, Xu Z, Zaleska MM, Zeldis J, Zhang M, Zhou H, Jacobsen JS. J Med Chem. 2008 Dec 11;51(23):7348-51.
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