Bengamide B

• Supplier: Tocris Bioscience
• Catalog: 3681
• Prices: $129.00
• Sizes: 100 µg
• Function Type: Inhibitor
• Cas Number: 104947-69-5
• Chemical Name: (6E)-6,7,8,9-Tetradeoxy-N-[(3S,6S)-hexahydro-1-methyl-2-oxo-6-[(1-oxotetradecyl)oxy]-1H-azepin-3-yl]-8-methyl-2-O-methyl-D-gulo-Non-6-enonamide
• Formula: C32H58N2O8
• Molecular Weight: 598.81
• Purity: >97 %
• Description: Potent inhibitor of NF- κ B activation (IC 50 = 85 nM); decreases I κ B α phosphorylation. Attenuates LPS-induced nitric oxide production and expression of TNF- α , IL-6 and MCP. Suppresses proliferation of HeLa and HCT116 cells. Anti-inflammatory and antitumor.

Product References

Synthesis and antitumor activity of ester-modified analogues of bengamide B. - Synthesis and antitumor activity of ester-modified analogues of bengamide B.

Kinder FR Jr, Versace RW, Bair KW, Bontempo JM, Cesarz D, Chen S, Crews P, Czuchta AM, Jagoe CT, Mou Y, Nemzek R, Phillips PE, Tran LD, Wang RM, Weltchek S, Zabludoff S. J Med Chem. 2001 Oct 25;44(22):3692-9.

Regulation of c-Src nonreceptor tyrosine kinase activity by bengamide A through - Regulation of c-Src nonreceptor tyrosine kinase activity by bengamide A through

Hu X, Dang Y, Tenney K, Crews P, Tsai CW, Sixt KM, Cole PA, Liu JO. Chem Biol. 2007 Jul;14(7):764-74.

Myxobacteria versus sponge-derived alkaloids: the bengamide family identified as - Myxobacteria versus sponge-derived alkaloids: the bengamide family identified as

Johnson TA, Sohn J, Vaske YM, White KN, Cohen TL, Vervoort HC, Tenney K, Valeriote FA, Bjeldanes LF, Crews P. Bioorg Med Chem. 2012 Jul 15;20(14):4348-55.