Benzamil

• Supplier: Tocris Bioscience
• Catalog: 3934
• Prices: $69.00, $275.00
• Sizes: 10 mg, 50 mg
• Function Type: Blocker
• Cas Number: 161804-20-2
• Chemical Name: N-(Benzylamidino)-3,5-diamino-6-chloropyrazinecarboxamidehydrochloride
• Formula: C13H14ClN7O.HCl
• Molecular Weight: 356.21
• Purity: >98 %
• Description: Na + /Ca 2+ exhanger (NCX) inhibitor (IC 50 ~ 100 nM); TRPP3 channel blocker (IC 50 = 1.1 μ M for inhibition of Ca 2+ -activated TRPP3 channel activity). Also non-selective Deg/ENaC family blocker; reduces mechanosensitivity of colonic afferents. More potent derivative of amiloride (Cat. No. 0890).

Product References

Characterization of a Na(+)-Ca(2+) exchanger in podocytes. - Characterization of a Na(+)-Ca(2+) exchanger in podocytes.

Fischer KG, Jonas N, Poschenrieder F, Cohen C, Kretzler M, Greiber S, Pavenstadt H. Nephrol Dial Transplant. 2002 Oct;17(10):1742-50.

Inhibition of TRPP3 channel by amiloride and analogs. - Inhibition of TRPP3 channel by amiloride and analogs.

Dai XQ, Ramji A, Liu Y, Li Q, Karpinski E, Chen XZ. Mol Pharmacol. 2007 Dec;72(6):1576-85. Epub 2007 Sep 5.

Acid sensing ion channels 2 and 3 are required for inhibition of visceral - Acid sensing ion channels 2 and 3 are required for inhibition of visceral

Page AJ, Brierley SM, Martin CM, Hughes PA, Blackshaw LA. Pain. 2007 Dec 15;133(1-3):150-60. Epub 2007 Apr 27.