BETP

• Supplier: Tocris Bioscience
• Catalog: 0906
• Prices: $179.00, $745.00
• Sizes: 10 mg, 50 mg
• Function Type: Modulator
• Cas Number: 1371569-69-5
• Chemical Name: 2-(Ethylsulfinyl)-4-[3-(phenylmethoxy)phenyl]-6-(trifluoromethyl)pyrimidine
• Formula: C20H17F3N2O2S
• Molecular Weight: 406.42
• Purity: >98 %
• Description: Selective positive allosteric modulator and partial agonist of the glucagon-like peptide 1 (GLP-1) receptor. Increases binding affinity of oxyntomodulin for the GLP-1 receptor. Potentiates oxyntomodulin-mediated GLP-1 receptor signaling in vitro and insulin secretion in vivo . Has no effect on GLP-2, GIP, PTH or glucagon receptors.

Product References

Novel small molecule glucagon-like peptide-1 receptor agonist stimulates insulin - Novel small molecule glucagon-like peptide-1 receptor agonist stimulates insulin

Sloop KW, Willard FS, Brenner MB, Ficorilli J, Valasek K, Showalter AD, Farb TB, Cao JX, Cox AL, Michael MD, Gutierrez Sanfeliciano SM, Tebbe MJ, Coghlan MJ. Diabetes. 2010 Dec;59(12):3099-107.

Two small molecule agonists of glucagon-like peptide-1 receptor modulate the - Two small molecule agonists of glucagon-like peptide-1 receptor modulate the

Cheong YH, Kim MK, Son MH, Kaang BK. Biochem Biophys Res Commun. 2012 Jan 6;417(1):558-63. doi:

Small molecule allosteric modulation of the glucagon-like Peptide-1 receptor - Small molecule allosteric modulation of the glucagon-like Peptide-1 receptor

Willard FS, Wootten D, Showalter AD, Savage EE, Ficorilli J, Farb TB, Bokvist K, Alsina-Fernandez J, Furness SG, Christopoulos A, Sexton PM, Sloop KW. Mol Pharmacol. 2012 Dec;82(6):1066-73.