| Name | BGC 20-1531 hydrochloride |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 0348 |
| Prices | $299.00 |
| Sizes | 10 mg |
| Function Type | Antagonist |
| Chemical Name | 4-[[4-(5-Methoxy-2-pyridinyl)phenoxy]methyl]-5-methyl-N-[(2-methylphenyl)sulfonyl]-2-furancarboxamidehydrochloride |
| Formula | C26H24N2O6S.HCl |
| Molecular Weight | 529 |
| Purity | >98 % |
| Description | High affinity and selective EP 4 antagonist (K i = 3 nM). Exhibits >2500-fold selectivity for EP 4 over EP 2 and EP 3 . Also selective over a range of other prostanoid receptors, ion channels, transporters and enzymes. Inhibits PGE 2 -induced vasodilation of middle cerebral and meningeal arteries in vitro , and carotid blood flow in vivo . Orally bioavailable. |
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Glennon RA, Lee M, Rangisetty JB, Dukat M, Roth BL, Savage JE, McBride A, Rauser L, Hufeisen S, Lee DK. J Med Chem. 2000 Mar 9;43(5):1011-8.
Mitchell ES, Hoplight BJ, Lear SP, Neumaier JF. Neuropharmacology. 2006 Mar;50(4):412-20. Epub 2005 Nov 18.