| Name | BI 9564 |
|---|---|
| Supplier | Tocris Bioscience |
| Catalog | 3314 |
| Prices | $189.00 |
| Sizes | 10 mg |
| Function Type | Inhibitor |
| Cas Number | 1883429-22-8 |
| Chemical Name | 4-[4-[(Dimethylamino)methyl]-2,5-dimethoxyphenyl]-2-methyl-1,2-dihydro-2,7-naphthyridin-1-one |
| Formula | C20H23N3O3 |
| Molecular Weight | 353.41 |
| Purity | >98 % |
| Description | Potent and selective BRD9 and BRD7 inhibitor (K d values are 14 and 239 nM, respectively). Exhibits selectivity for BRD9/7 over 48 other bromodomains, 324 kinases and 55 GPCRs. Inhibits proliferation of AML cell lines in vitro and reduces AML tumor xenograft growth in vivo . Cell permeable and orally active. |
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Doods H, Hallermayer G, Wu D, Entzeroth M, Rudolf K, Engel W, Eberlein W. Br J Pharmacol. 2000 Feb;129(3):420-3.
Rudolf K, Eberlein W, Engel W, Pieper H, Entzeroth M, Hallermayer G, Doods H. J Med Chem. 2005 Sep 22;48(19):5921-31.