BIBP 3226 trifluoroacetate

Name BIBP 3226 trifluoroacetate
Supplier Tocris Bioscience
Catalog 2412
Prices $129.00, $279.00
Sizes 1 mg, 10 mg
Function Type Antagonist
Chemical Name N-[(1R)]-4-[(Aminoiminomethyl)amino-1-[[[(4-hydroxyphenyl)methyl]amino]carbonyl]butyl-α-phenylbenzeneacetamideditrifluoroacetate
Formula C27H31N5O3.2CF3CO2H
Molecular Weight 701.61
Purity >98 %
Description Mixed non-peptide neuropeptide Y Y 1 (NPY Y 1 ) and neuropeptide FF (NPFF) receptor antagonist (K i values are 1.1, 79, 108, > 1000, > 1000 and >1000 for rNPY Y 1 , hNPFF 2 , rNPFF, rNPY Y 2 , rNPY Y 4 and rNPY Y 5 respectively). Produces an anxiogenic-like effect in rats following i.c.v. administration.
Supplier Page Shop

Product References

Anxiogenic-like effect of the neuropeptide Y Y1 receptor antagonist BIBP3226: - Anxiogenic-like effect of the neuropeptide Y Y1 receptor antagonist BIBP3226:

Kask A, Rago L, Harro J. Eur J Pharmacol. 1996 Dec 19;317(2-3):R3-4.

Agonist and antagonist activities on human NPFF(2) receptors of the NPY ligands - Agonist and antagonist activities on human NPFF(2) receptors of the NPY ligands

Mollereau C, Gouarderes C, Dumont Y, Kotani M, Detheux M, Doods H, Parmentier M, Quirion R, Zajac JM. Br J Pharmacol. 2001 May;133(1):1-4.

In vivo inhibition of neuropeptide FF agonism by BIBP3226, an NPY Y1 receptor - In vivo inhibition of neuropeptide FF agonism by BIBP3226, an NPY Y1 receptor

Fang Q, Guo J, He F, Peng YL, Chang M, Wang R. Peptides. 2006 Sep;27(9):2207-13. Epub 2006 Jun 9.