BIBR 1532

• Supplier: Tocris Bioscience
• Catalog: 2707
• Prices: $185.00, $755.00
• Sizes: 10 mg, 50 mg
• Function Type: Inhibitor
• Cas Number: 321674-73-1
• Chemical Name: 2-[[(2E)-3-(2-Naphthalenyl)-1-oxo-2-butenyl1-yl]amino]benzoicacid
• Formula: C21H17NO3
• Molecular Weight: 331.36
• Purity: >98 %
• Description: Selective telomerase inhibitor (IC 50 values are 93, > 100000 and > 100000 nM for human telomerase, human RNA polymerase I and human RNA polymerase II + III respectively). Causes telomere shortening in exponentially growing NCI-H460 lung carcinoma cells and eventual growth arrest.

Product References

A highly selective telomerase inhibitor limiting human cancer cell proliferation. - A highly selective telomerase inhibitor limiting human cancer cell proliferation.

Damm K, Hemmann U, Garin-Chesa P, Hauel N, Kauffmann I, Priepke H, Niestroj C, Daiber C, Enenkel B, Guilliard B, Lauritsch I, Muller E, Pascolo E, Sauter G, Pantic M, Martens UM, Wenz C, Lingner J, Kraut N, Rettig WJ, Schnapp A. EMBO J. 2001 Dec 17;20(24):6958-68.

Telomerase and its potential for therapeutic intervention. - Telomerase and its potential for therapeutic intervention.

Phatak P, Burger AM. Br J Pharmacol. 2007 Dec;152(7):1003-11. Epub 2007 Jul 2.

Telomerase inhibitors and 'T-oligo' as cancer therapeutics: contrasting molecular - Telomerase inhibitors and 'T-oligo' as cancer therapeutics: contrasting molecular

Rankin AM, Faller DV, Spanjaard RA. Anticancer Drugs. 2008 Apr;19(4):329-38.